Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
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چکیده
منابع مشابه
Localization and topogenesis studies of cytoplasmic and vacuolar homologs of the Galanthus nivalis agglutinin.
The Galanthus nivalis agglutinin (GNA) is synthesized as a preproprotein. To corroborate the role of the different targeting peptides in the topogenesis of GNA and related proteins, different constructs were made whereby both the complete original GNA gene and different truncated sequences were coupled to the enhanced green fluorescent protein (EGFP). In addition, a GNA ortholog from rice that ...
متن کاملBiosynthesis of the Snowdrop (Galanthus nivalis) Lectin in Ripening Ovaries.
The biosynthesis and processing of the Galanthus nivalis agglutinin were studied in vivo in ripening snowdrop ovaries. Using labeling and pulse chase labeling experiments it could be demonstrated that the snowdrop lectin is synthesized as a precursor of relative molecular weight (M(r)) 15,000 which is posttranslationally converted into the authentic lectin polypeptide of M(r) 13,000 with a half...
متن کاملEffect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine.
Diets containing genetically modified (GM) potatoes expressing the lectin Galanthus nivalis agglutinin (GNA) had variable effects on different parts of the rat gastrointestinal tract. Some effects, such as the proliferation of the gastric mucosa, were mainly due to the expression of the GNA transgene. However, other parts of the construct or the genetic transformation (or both) could also have ...
متن کاملBiosynthesis, primary structure and molecular cloning of snowdrop (Galanthus nivalis L.) lectin.
Poly(A)-rich RNA isolated from ripening ovaries of snowdrop (Galanthus nivalis L.) yielded a single 17-kDa lectin polypeptide upon translation in a wheat-germ cell-free system. This lectin was purified by affinity chromatography. Translation of the same RNA in Xenopus leavis oocytes revealed a lectin polypeptide which was about 2 kDa smaller than the in vitro synthesized precursor, suggesting t...
متن کاملEffects of Snowdrop Lectin (Galanthus nivalis Agglutinin) Expressed in Transgenic Sugarcane on Fitness of Cotesia flavipes (Hymenoptera: Braconidae), a Parasitoid of the Nontarget Pest Diatraea saccharalis (Lepidoptera: Crambidae)
Cotesia flavipes (Cameron) is a parasitoid responsible for maintaining populations of sugarcane borer, Diatraea saccharalis (F.), below economic levels in south Texas sugarcane Þelds. Transgenic sugarcane expressing the snowdrop lectin (Galanthus nivalis agglutinin, GNA) was developed against the Mexican rice borer, Eoreuma loftini (Dyar), the primary pest of south Texas sugarcane. The potentia...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2010
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2010.06.010